Zebrafish usp3 loss found to promote hypoxic tolerance
by KeAi Communications Co. HIF-1α can stabilize its protein through K63-linked polyubiquitination under hypoxia, stabilized HIF1α proteins dimerize with HIF1β proteins, translocate to the nucleus, and induce transcription of genes involved in adaptation or tolerance to hypoxia. USP3 deubiquitinates K63-linked polyubiquitination of HIF-1α to induce HIF-1α degradation and suppress hypoxia signaling. Credit: J. Li et
Tomi Stoval
January 30, 2024