Rational design of mRNA nanovaccine for cancer immunotherapy
(a) Anionic Lipo-ORG enabled effective access to lymphatics and high accumulation in lymph nodes. Effective cellular entry and endosome escape of mRNA and cGAMP was achieved in DCs and potentiated antigen presentation to T cells. Tumor antigens were presented after the release of mRNA. cGAMP activated STING pathway to trigger IFN-I, which amplified the innate
Tama Mischke
October 17, 2023