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Notch signaling and insm1a expression are dynamic and spatially distinct during olfactory neurogenesis. Credit: Stem Cell Reports (2025). DOI: 10.1016/j.stemcr.2025.102575 Cellular differentiation of stem cells into specialized cells requires many steps, including division, to create more cells; fate determination, which is a commitment to a specific lineage or developmental path; and migration, to integrate the
An infographic explaining the new findings about cell proliferation. Credit: Lucy Reading-Ikkanda/Simons Foundation Like so many organisms on the planet, when cells experience mosh-pit-level crowding, they may just become stressed. Yet unlike most other life forms, cells subject to physical stress from crowding by neighbors can find some relief by dramatically slowing their own growth—and
A hibernating dormouse. Credit: Zoë Helene Kindermann, CC-BY-SA-4.0 Developing approaches to protect human well-being in a changing climate will depend on a deeper understanding of how mammalian cells and organisms adapt to dramatic shifts in temperature and in the availability of food and water. To help build this knowledge base, Institute researchers are exposing cells…