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Rational design of mRNA nanovaccine for cancer immunotherapy

(a) Anionic Lipo-ORG enabled effective access to lymphatics and high accumulation in lymph nodes. Effective cellular entry and endosome escape of mRNA and cGAMP was achieved in DCs and potentiated antigen presentation to T cells. Tumor antigens were presented after the release of mRNA. cGAMP activated STING pathway to trigger IFN-I, which amplified the innate

Rite Aid files for Chapter 11 bankruptcy

Pharmacy retailer Rite Aid filed for Chapter 11 bankruptcy protection on Sunday as it struggled with rising debt, falling sales and intense competition from rivals like Walgreens and CVS…Read More

Montgomery, Rangers take 1-0 lead on Astros in ALCS

Jordan Montgomery allowed five hits and no runs over 6 1/3 innings to lead the Texas Rangers to a 2-0 win over the Houston Astros in Game 1 of the American League Championship Series…Read More

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