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by Frederike Buhse, Exzellenzcluster Präzisionsmedizin für chronische Entzündungserkrankungen
The study identified two messenger substances that cause persistent inflammation in the nasal mucosa. This inflammatory process appears to inhibit tissue regeneration and thus contributes to the ongoing symptoms of post-COVID syndrome.
The findings have been published in Nature Communications.
Post-COVID syndrome (PCS) affects approximately 3–17% of individuals following infection with the SARS-CoV-2 coronavirus. Those affected suffer from late or long-term effects with a wide range of symptoms, the causes of which remain largely unclear.
The team led by Dr. Karosham Reddy and Professor Markus Weckmann (both FZB), Professor Hauke Busch, and Associate Professor Dr. Anke Fähnrich from the Medical Systems Biology group at the Lübeck Institute of Experimental Dermatology (LIED), examined nasal biopsy samples from 25 patients with post-COVID syndrome at the cellular and molecular levels. The samples were collected as part of NAPKON, a nationwide post-COVID cohort.
The researchers analyzed, among other things, the existing cell types and the signaling pathways through which the cells communicate. They discovered that the mucosa of the upper respiratory tract remains structurally altered even months after recovery from a SARS-CoV-2 infection—despite the absence of an active viral infection.
More information:
K. D. Reddy et al, scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome, Nature Communications (2025). DOI: 10.1038/s41467-025-64778-0
Provided by
Exzellenzcluster Präzisionsmedizin für chronische Entzündungserkrankungen
Citation:
New molecular drivers of long COVID link nasal inflammation to lingering symptoms (2025, November 7)
retrieved 7 November 2025
from https://phys.org/news/2025-11-molecular-drivers-covid-link-nasal.html
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