Generation of a human haploid neural stem cell line for genome-wide genetic screening

Marquis Fleishman
July 27, 2023

Characterization of the pluripotency and haploidy of extended pluripotent human haploid embryonic stem cells. Credit: World Journal of Stem Cells (2023). DOI: 10.4252/wjsc.v15.i7.734 Haploid embryonic stem cells (haESCs) have been established in many species. Differentiated haploid cell line types in mammals are lacking due to spontaneous diploidization during differentiation that compromises lineage-specific screens. Recently, a

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screening. To date, no human haploid somatic cell lines have been successfully created. The researchers converted human haploid embryonic stem cells to an extended pluripotency state by optimizing the culture medium. The derived haploid neural stem cells can proliferate as a haploid genome and maintain multipotency to generate functional neurons and glia. The haploid neural stem cells can also be easily used for gene editing to generate numerous homozygous mutations for lineage-specific screens.

More information:
Hai-Song Wang et al, Generation of a human haploid neural stem cell line for genome-wide genetic screening, World Journal of Stem Cells (2023). DOI: 10.4252/wjsc.v15.i7.734

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World Journal of Stem Cells

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Generation of a human haploid neural stem cell line for genome-wide genetic screening (2023, July 26)
retrieved 27 July 2023
from https://phys.org/news/2023-07-generation-human-haploid-neural-stem.html

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Generation of a human haploid neural stem cell line for genome-wide genetic screening

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