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“Our data shed light on the mechanisms of action of many assembly factors that long-awaited structural characterization and reveal novel exciting evolutionary adaptations of the human mitochondrial translation system,” says Joanna Rorbach, Assistant Professor at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet, one of the senior authors of the study.
“This study greatly contributes to our understanding of the complex process of mitoribosome biogenesis and will help to better understand human diseases and development of new therapeutics,” says Martin Hällberg, Senior Researcher at the Department of Cell and Molecular Biology, one of the senior authors of the study.
Miriam Cipullo et al, Structural basis for late maturation steps of the human mitoribosomal large subunit, Nature Communications (2021). DOI: 10.1038/s41467-021-23617-8
Mitochondrial ribosome assembly in 3D (2021, June 16)
retrieved 16 June 2021
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